Progress in the function and regulation of ADP-Ribosylation.

  title={Progress in the function and regulation of ADP-Ribosylation.},
  author={Michael O Hottiger and Mark R. Boothby and Friedrich Koch-Nolte and Bernhard L{\"u}scher and N. M. Martin and Ruth Plummer and Zhao-Qi Wang and Mathias Ziegler},
  journal={Science signaling},
  volume={4 174},
Adenosine 5'-diphosphate (ADP)-ribosylation is a protein posttranslational modification that is catalyzed by ADP-ribosyltransferases (ARTs), using nicotinamide adenine dinucleotide (NAD(+)) as a substrate. Mono-ribosylation can be extended into polymers of ADP-ribose (PAR). Poly(ADP-ribosyl)polymerase (PARP) 1, the best-characterized cellular enzyme catalyzing this process, is the prototypical member of a family of mono- and poly(ADP-ribosyl)transferases. The physiological consequences of ADP… CONTINUE READING


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From bench to bedside

  • C. Underhill, M. Toulmonde, H. Bonnefoi, A review of PARP inhibitors
  • Ann. Oncol. 22, 268–279
  • 2010
1 Excerpt

PARP1 and beyond

  • M. Rouleau, A. Patel, M. J. Hendzel, S. H. Kaufmann, G. G. Poirier, PARP inhibition
  • Nat. Rev. Cancer 10, 293–301
  • 2010
1 Excerpt

Where are we today and where are we going? Microbiol

  • P. O. Hassa, S. S. Haenni, M. Elser, M. O. Hottiger, Nuclear ADP-ribosylation reactions in mammalian cells
  • Mol. Biol. Rev. 70, 789–829
  • 2006
2 Excerpts

Targeting eukaryotic switches

  • K. Aktories, J. T. Barbieri, Bacterial cytotoxins
  • Nat. Rev. Microbiol. 3, 397–410
  • 2005
1 Excerpt

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