Progress in the function and regulation of ADP-Ribosylation.

@article{Hottiger2011ProgressIT,
  title={Progress in the function and regulation of ADP-Ribosylation.},
  author={Michael O Hottiger and Mark R. Boothby and Friedrich Koch-Nolte and Bernhard L{\"u}scher and N. M. Martin and Ruth Plummer and Zhao-Qi Wang and Mathias Ziegler},
  journal={Science signaling},
  year={2011},
  volume={4 174},
  pages={mr5}
}
Adenosine 5'-diphosphate (ADP)-ribosylation is a protein posttranslational modification that is catalyzed by ADP-ribosyltransferases (ARTs), using nicotinamide adenine dinucleotide (NAD(+)) as a substrate. Mono-ribosylation can be extended into polymers of ADP-ribose (PAR). Poly(ADP-ribosyl)polymerase (PARP) 1, the best-characterized cellular enzyme catalyzing this process, is the prototypical member of a family of mono- and poly(ADP-ribosyl)transferases. The physiological consequences of ADP… CONTINUE READING

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