Progress in the discovery and development of glutamate carboxypeptidase II inhibitors.

@article{Tsukamoto2007ProgressIT,
  title={Progress in the discovery and development of glutamate carboxypeptidase II inhibitors.},
  author={Takashi Tsukamoto and Krystyna M. Wozniak and Barbara S Slusher},
  journal={Drug discovery today},
  year={2007},
  volume={12 17-18},
  pages={767-76}
}
During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from… CONTINUE READING

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