Progress in the development of selective nitric oxide synthase (NOS) inhibitors.

  title={Progress in the development of selective nitric oxide synthase (NOS) inhibitors.},
  author={L. Salerno and V. Sorrenti and C. Di Giacomo and G. Romeo and M. Siracusa},
  journal={Current pharmaceutical design},
  volume={8 3},
Nitric oxide (NO), a molecular messenger synthesized by nitric oxide synthase (NOS) from L-arginine and molecular oxygen, is involved in a number of physiological and pathological processes in mammalians. Three structurally distinct isoforms of NOS have been identified: neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). Although NO mediates several physiological functions, overproduction of NO by nNOS has been reported in a number of clinical disorders including acute (stroke) and… Expand
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