Progress in the Understanding of the Pathology and Pathogenesis of Cutaneous Drug Eruptions

@article{Crowson2003ProgressIT,
  title={Progress in the Understanding of the Pathology and Pathogenesis of Cutaneous Drug Eruptions},
  author={A. Neil Crowson and Tricia J. Brown and Cynthia M. Magro},
  journal={American Journal of Clinical Dermatology},
  year={2003},
  volume={4},
  pages={407-428}
}
Cutaneous drug eruptions are among the most common adverse reactions to drug therapy. The etiology may reflect immunologic or nonimmunologic mechanisms, the former encompassing all of the classic Gell and Combs immune mechanisms. Cumulative and synergistic effects of drugs include those interactions of pharmacokinetic and pharmacodynamic factors reflecting the alteration by one drug of the effective serum concentration of another and the functions of drugs and their metabolites that interact to… CONTINUE READING

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