Progress in the Medicinal Chemistry of Group III Metabotropic Glutamate Receptors

@inproceedings{Liu2011ProgressIT,
  title={Progress in the Medicinal Chemistry of Group III Metabotropic Glutamate Receptors},
  author={Kevin G. Liu and Dario Doller},
  year={2011}
}
Publisher Summary This chapter focuses on the recent progress on identification of group III metabotropic glutamate (mGlu) receptor ligands that belong to the class C G-protein-coupled receptor family and are activated by L-glutamate, a major excitatory neurotransmitter of the mammalian brain. Eight subtypes of mGlu receptors are identified and divided into three groups based on sequence homology, signal transduction, and pharmacology. The widespread expression of mGlu receptors and their role… CONTINUE READING