Progress in the Development of Alternative Pharmaceutical Formulations of Taxanes

@article{Nuijen2001ProgressIT,
  title={Progress in the Development of Alternative Pharmaceutical Formulations of Taxanes},
  author={Bastiaan Nuijen and Marjan Bouma and Jan H. M. Schellens and Jos H. Beijnen},
  journal={Investigational New Drugs},
  year={2001},
  volume={19},
  pages={143-153}
}
The currently available taxanes paclitaxel(Taxol®) and docetaxel(Taxotere®) are clinically effectiveagainst advanced breast, ovarian andnon-small cell lung cancer. Due to theirlow aqueous solubility, both taxanes poseddifficulties to the pharmaceuticalscientists with respect to the developmentof an intravenous dosage form. At present,paclitaxel is formulated in a mixture of50:50% (v/v) Cremophor EL and dehydratedethanol. However, this formulation vehicleis associated with a number… CONTINUE READING
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