Progress in matrix metalloproteinase research.

  title={Progress in matrix metalloproteinase research.},
  author={Gillian Murphy and Hideaki Nagase},
  journal={Molecular aspects of medicine},
  volume={29 5},
Matrix metalloproteinases (MMPs) are now acknowledged as key players in the regulation of both cell-cell and cell-extracellular matrix interactions. They are involved in modifying matrix structure, growth factor availability and the function of cell surface signalling systems, with consequent effects on cellular differentiation, proliferation and apoptosis. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury and in the progression of… CONTINUE READING
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