Progress in brain penetration evaluation in drug discovery and development.

@article{Liu2008ProgressIB,
  title={Progress in brain penetration evaluation in drug discovery and development.},
  author={Xingrong Liu and Cuiping Chen and Bill J. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={325 2},
  pages={349-56}
}
This review discusses strategies to optimize brain penetration from the perspective of drug discovery and development. Brain penetration kinetics can be described by the extent and time to reach brain equilibrium. The extent is defined as the ratio of free brain concentration to free plasma concentration at steady state. For all central nervous system (CNS) drug discovery programs, optimization of the extent of brain penetration should focus on designing and selecting compounds having low… CONTINUE READING

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