Progress in applying genomics in drug development.

@article{Lord2003ProgressIA,
  title={Progress in applying genomics in drug development.},
  author={Peter G. Lord},
  journal={Toxicology letters},
  year={2003},
  volume={149 1-3},
  pages={
          371-5
        }
}
Genomics has had an impact on two areas of drug development, "predictive" toxicology and mechanism-based risk assessment. Predictive toxicology studies are aimed at identifying the potential for a compound to be toxic. By developing databases of expression profiles for a wide variety of toxic compounds and toxic models it has been possible to create statistical and computational methods which provide an indication of the toxic potential of a drug from the pattern of gene expression changes it… CONTINUE READING

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