Progress in Top-Down Proteomics and the Analysis of Proteoforms.

  title={Progress in Top-Down Proteomics and the Analysis of Proteoforms.},
  author={Timothy K. Toby and Luca Fornelli and Neil L. Kelleher},
  journal={Annual review of analytical chemistry},
  volume={9 1},
From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 years, mass spectrometry (MS) has become a powerful method for the analysis of proteomes. Prevailing bottom-up proteomics operates at the level of the peptide, leading to issues with protein inference, connectivity, and incomplete sequence/modification information. Top-down proteomics (TDP), alternatively… CONTINUE READING
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