Progress in Top-Down Proteomics and the Analysis of Proteoforms.

@article{Toby2016ProgressIT,
  title={Progress in Top-Down Proteomics and the Analysis of Proteoforms.},
  author={Timothy K. Toby and Luca Fornelli and Neil L. Kelleher},
  journal={Annual review of analytical chemistry},
  year={2016},
  volume={9 1},
  pages={
          499-519
        }
}
From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 years, mass spectrometry (MS) has become a powerful method for the analysis of proteomes. Prevailing bottom-up proteomics operates at the level of the peptide, leading to issues with protein inference, connectivity, and incomplete sequence/modification information. Top-down proteomics (TDP), alternatively… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Ancient Biomolecules and Evolutionary Inference.

Annual review of biochemistry • 2018
View 1 Excerpt

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Proceedings of the National Academy of Sciences of the United States of America • 2018
View 2 Excerpts

Similar Papers

Loading similar papers…