Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application

@article{Aarts2011ProgressAP,
  title={Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application},
  author={Marieke Aarts and Hein P. J. te Riele},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={213-219}
}
Gene targeting by single-stranded oligodeoxyribonucleotides (ssODNs) is a promising technique for introducing site-specific sequence alterations without affecting the genomic organization of the target locus. Here, we discuss the significant progress that has been made over the last 5 years in unraveling the mechanisms and reaction parameters underlying ssODN-mediated gene targeting. We will specifically focus on ssODN-mediated gene targeting in murine embryonic stem cells (ESCs) and the impact… CONTINUE READING

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