Progress and problems in vaccination against necrotic enteritis in broiler chickens

@article{Mot2014ProgressAP,
  title={Progress and problems in vaccination against necrotic enteritis in broiler chickens},
  author={Dorien Mot and Leen Timbermont and Freddy Haesebrouck and Richard Ducatelle and Filip Van Immerseel},
  journal={Avian Pathology},
  year={2014},
  volume={43},
  pages={290 - 300}
}
Necrotic enteritis in broilers is caused by Clostridium perfringens type A strains that produce the NetB toxin. Necrotic enteritis is one of the gastrointestinal diseases in poultry that has gained worldwide importance during the last decade due to efforts to improve broiler performance. Prevention strategies include avoiding predisposing factors, such as coccidiosis, and in-feed supplementation with a variety of feed additives. However, vaccination with modified toxin or other secreted… Expand
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TLDR
Results suggest that immunoprophylaxis seems to be an interesting alternative for the control of necrotic enteritis in broilers. Expand
Day-of-hatch vaccination is not protective against necrotic enteritis in broiler chickens
TLDR
Double vaccination with crude supernatant resulted in a significant decrease in the number of chickens with necrotic enteritis lesions, while vaccination of 1-day-old chickens with crudesupernatant or toxoid, as envisaged for practical field application, did not induce protection. Expand
Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis
TLDR
It is suggested that vaccination with NetB alone may not be sufficient to protect birds from necrotic enteritis in the field, but that in combination with other cellular or cell-free antigens it can significantly protect chickens from disease. Expand
The successful experimental induction of necrotic enteritis in chickens by Clostridium perfringens: a critical review
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A standardized scoring system is proposed for international adoption based on gross rather than histopathological lesions; if universally adopted this will allow better comparison between studies done by different researchers, and a scores system is provided to assist decisions on humane euthanasia of sick birds. Expand
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TLDR
There are certain secreted proteins, in addition to alpha-toxin, that are involved in immunity to NE in broiler chickens, which are concluded to be uniquely produced by virulent C. perfringens. Expand
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TLDR
Results suggest that alpha toxin may serve as an effective immunogen, and, as such, may play a role in pathogenesis of necrotic enteritis in poultry. Expand
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TLDR
The results indicate that the protective characteristics of the supernatants are not solely based on the presence of NetB or alpha toxin. Expand
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TLDR
It is concluded that it is possible to immunize chickens successfully against necrotic enteritis and that immunogen(s) other than alpha-toxin are important in protective immunity against oral infection. Expand
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TLDR
Results indicate that, under commercial conditions, maternal vaccination with Netvax™ can help to control losses related to necrotic enteritis. Expand
Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis
TLDR
It is demonstrated that maternal immunization with a NetB-enhanced toxoid vaccine is a promising method for the control of necrotic enteritis in young broiler chickens. Expand
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