Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.

@article{Aguzzi2004ProgressAP,
  title={Progress and problems in the biology, diagnostics, and therapeutics of prion diseases.},
  author={Adriano Aguzzi and Mathias Heikenwalder and Gino Miele},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={114 2},
  pages={153-60}
}
The term "prion" was introduced by Stanley Prusiner in 1982 to describe the atypical infectious agent that causes transmissible spongiform encephalopathies, a group of infectious neurodegenerative diseases that include scrapie in sheep, Creutzfeldt-Jakob disease in humans, chronic wasting disease in cervids, and bovine spongiform encephalopathy in cattle. Over the past twenty years, the word "prion" has been taken to signify various subtly different concepts. In this article, we refer to the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 97 references

A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…