Progress: Neurogenesis in adult primate neocortex: an evaluation of the evidence

@article{Rakic2002ProgressNI,
  title={Progress: Neurogenesis in adult primate neocortex: an evaluation of the evidence},
  author={Pasko Rakic},
  journal={Nature Reviews Neuroscience},
  year={2002},
  volume={3},
  pages={65-71}
}
  • P. Rakic
  • Published 2002
  • Biology, Medicine
  • Nature Reviews Neuroscience
Reports of continuous genesis and turnover of neurons in the adult primate association neocortex — the site of the highest cognitive functions — have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim. 
Adult Neurogenesis in Mammals: An Identity Crisis
  • P. Rakic
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2002
The study of neurogenesis in the adult brain is among the most exciting and fastest moving areas of neuroscience today. In contrast to the high rate of neurogenesis in some vertebrates ([Nottebohm,Expand
Neurogenesis in the adult hippocampus
TLDR
The dentate gyrus (DG) contains one of the few neuronal populations in the mammalian brain that are generated throughout life and some of the methods most commonly used for studying these processes. Expand
Postnatal Neurogenesis and Neuronal Regeneration
TLDR
This work has confirmed neurogenetical capability in discrete regions of several mammalian species including humans, which may serve as the basis for neuronal regeneration, as has already been described in the reptilian brain, and thus may represent a promising therapeutic approach. Expand
THE BIOLOGICAL RESTORATION OF CENTRAL NERVOUS SYSTEM ARCHITECTURE AND FUNCTION: PART 2—EMERGENCE OF THE REALIZATION OF ADULT NEUROGENESIS
TLDR
This second article in a 5-part series on stem cells traces the milestones that gave birth to a new era in neuroscience: the realization of adult mammalian neurogenesis. Expand
Evidence of adult neurogenesis in non-human primates and human
TLDR
The differences between rodent, primate and human neurogenesis may contribute to distinct physiological roles and the self-repair mechanisms in the brain across species. Expand
Mechanisms and Functional Implications of Adult Neurogenesis
TLDR
The factors that regulate proliferation and fate determination of adult neural stem cells are discussed and the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease is addressed. Expand
Neuroscience: Immigration denied
The adult human brain cannot replace lost neurons. This might be because it is reluctant to accept newcomers into an already established neural network, rather than because potential progenitors areExpand
No More Cortical Neurons for You
TLDR
An advanced method of cell birth dating appears to answer the contentious question of whether new neurons are born in the cortex of the adult human brain in the negative. Expand
Newborn cortical neurons: only for neonates?
TLDR
Evidence of the existence, origin, migration, and integration of neurons into the adult and neonatal cerebral cortex is reviewed and it is found that neurogenesis occurs in the neonatal cortex and that neural stem cells are present into adulthood. Expand
Nonrenewal of Neurons in the Cerebral Neocortex of Adult Macaque Monkeys
TLDR
It is concluded that, in the normal condition, cortical neurons of adult primates, similar to other mammalian species, are neither supplemented nor renewable. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 92 REFERENCES
Neurogenesis in the adult brain: death of a dogma
  • C. Gross
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 2000
TLDR
This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse as a central assumption in the field of neuroscience. Expand
Adult Neurogenesis in Mammals: An Identity Crisis
  • P. Rakic
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2002
The study of neurogenesis in the adult brain is among the most exciting and fastest moving areas of neuroscience today. In contrast to the high rate of neurogenesis in some vertebrates ([Nottebohm,Expand
Neurogenesis in the neocortex of adult primates.
In primates, prefrontal, inferior temporal, and posterior parietal cortex are important for cognitive function. It is shown that in adult macaques, new neurons are added to these three neocorticalExpand
Are New Neurons Formed in the Brains of Adult Mammals?
In an autoradiographic investigation, the production of brain lesions in rats was combined with intracranial injection of thymidine-H3. Nuclei of numerous glia cells were found labeled in brainExpand
New neurons: extraordinary evidence or extraordinary conclusion?
TLDR
This remarkable finding explicitly challenges previous work indicating that the production of new neurons in the primate neocortex is limited to the fetal period and indicates that in the adult primate new neurons may be added to some neocortical association areas. Expand
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex
TLDR
The results do not substantiate the claim of neurogenesis in normal adult primate neocortex, and numerous BrdU-labeled cells were distributed throughout the cerebral wall, including the neocortex; evidence for newly generated neurons was limited to the hippocampus and olfactory bulb. Expand
Young neurons for old brains?
  • P. Rakic
  • Biology, Medicine
  • Nature Neuroscience
  • 1998
New evidence suggests that embryonic progenitor cells in the adult human hippocampus can generate new neurons; the results raise the possibility of therapeutic neuron replacement.
Limits of neurogenesis in primates.
TLDR
Autoradiograms from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons, suggesting a stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime. Expand
Continuation of neurogenesis in the hippocampus of the adult macaque monkey.
  • D. R. Kornack, P. Rakic
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
This demonstration of adult neurogenesis in nonhuman Old World primates-with their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities-establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogen Genesis in humans and offers new insights into its significance in the adult brain. Expand
DNA Synthesis and Cell Division in the Adult Primate Brain a
  • P. Rakic
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1985
Autoradiographic analysis of juvenile and adult monkeys that received single or multiple injection of the specific DNA precursor, [3H]thymidine, demonstrates slight turnover of glial cells, butExpand
...
1
2
3
4
5
...