Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease.

@article{Carecchio2009ProgranulinPL,
  title={Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease.},
  author={Miryam Carecchio and Chiara Fenoglio and Milena A De Riz and Ilaria Guidi and Cristoforo Comi and Francesca Cortini and Eliana Venturelli and Ilaria Restelli and Claudia Cantoni and Nereo Bresolin and Francesco Monaco and Elio Scarpini and Daniela Galimberti},
  journal={Journal of the neurological sciences},
  year={2009},
  volume={287 1-2},
  pages={291-3}
}
Progranulin (GRN) mutations are associated with different clinical phenotypes, including Frontotemporal Lobar Degeneration (FTLD), Corticobasal Degeneration and Alzheimer's disease (AD). In addition, the range of age at onset is very wide and patients presenting initial symptoms around eighty years have been described. Previous studies demonstrated that progranulin plasma levels determination may be a reliable method to identify GRN deletion carriers. We thus evaluated progranulin plasma levels… CONTINUE READING
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