Progranulin expression in advanced human atherosclerotic plaque.

  title={Progranulin expression in advanced human atherosclerotic plaque.},
  author={Yoji Kojima and Koh Ono and Katsumi Inoue and Yasushi Takagi and Ken-ichiro Kikuta and Masaki Nishimura and Yoshinori Yoshida and Yasuhiro Nakashima and Hironobu Matsumae and Yutaka Furukawa and Nobuhiro Mikuni and Masakiyo Nobuyoshi and Takeshi Kimura and Toru Kita and Makoto Tanaka},
  volume={206 1},
BACKGROUND Progranulin (PGRN) is a unique growth factor that plays an important role in cutaneous wound healing. It has an anti-inflammatory effect and promotes cell proliferation. However, when it is degraded to granulin peptides (GRNs) by neutrophil proteases, a pro-inflammatory reaction occurs. Since injury, inflammation and repair are common features in the progression of atherosclerosis, it is conceivable that PGRN plays a role in atherogenesis. RESULTS Immunohistochemical analysis of… CONTINUE READING
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