Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.

Abstract

Amyloid-beta (Abeta) plaques are pathological hallmarks of Alzheimer disease (AD). In addition, innate inflammatory responses, such as those mediated by microglia, are integral to the pathogenesis of AD. Interestingly, only dense-core plaques and not diffuse plaques are associated with neuritic and inflammatory pathology in AD patients as well as in mouse… (More)
DOI: 10.1002/path.2580

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Cite this paper

@article{Pereson2009ProgranulinEC, title={Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.}, author={Sandra Pereson and Hans Wils and Gernot Kleinberger and Eileen Marie Mcgowan and Mado Vandewoestyne and Bianca Van Broeck and Geert Joris and Ivy Cuijt and Dieter Deforce and M. Hutton and Christine Van Broeckhoven and Samir Kumar-Singh}, journal={The Journal of pathology}, year={2009}, volume={219 2}, pages={173-81} }