Progranulin-associated primary progressive aphasia: A distinct phenotype?

  title={Progranulin-associated primary progressive aphasia: A distinct phenotype?},
  author={Jonathan D. Rohrer and Sebastian J. Crutch and Elizabeth K. Warrington and Jason D Warren},
The neuropsychological features of the primary progressive aphasia (PPA) syndromes continue to be defined. Here we describe a detailed neuropsychological case study of a patient with a mutation in the progranulin (GRN) gene who presented with progressive word-finding difficulty. Key neuropsychological features in this case included gravely impoverished propositional speech with anomia and prolonged word-finding pauses, impaired speech repetition most marked for sentences, and severely impaired… CONTINUE READING
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