Progranulin: a growth factor, a novel TNFR ligand and a drug target.

  title={Progranulin: a growth factor, a novel TNFR ligand and a drug target.},
  author={Chuan-ju Liu and Xavier Bosch},
  journal={Pharmacology & therapeutics},
  volume={133 1},
Progranulin (PGRN) is abundantly expressed in epithelial cells, immune cells, neurons, and chondrocytes, and reportedly contributes to tumorigenesis. PGRN is a crucial mediator of wound healing and tissue repair. PGRN also functions as a neurotrophic factor and mutations in the PGRN gene resulting in partial loss of the PGRN protein cause frontotemporal dementia. PGRN has been found to be a novel chondrogenic growth factor and to play an important role in cartilage development and inflammatory… CONTINUE READING


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