Programming the brain and behaviour by early-life stress: a focus on neuroactive steroids.

@article{Brunton2015ProgrammingTB,
  title={Programming the brain and behaviour by early-life stress: a focus on neuroactive steroids.},
  author={Paula J. Brunton},
  journal={Journal of neuroendocrinology},
  year={2015},
  volume={27 6},
  pages={468-80}
}
Animal studies have amply demonstrated that stress exposure during pregnancy or in early postnatal life can adversely influence brain development and have long-term 'programming' effects on future brain function and behaviour. Furthermore, a growing body of evidence from human studies supports the hypothesis that some psychiatric disorders may have developmental origins. Here, the focus is on three adverse consequences of early-life stress: dysregulation of the hypothalamic-pituitary-adrenal… CONTINUE READING