Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway.

@article{Trevenzoli2010ProgrammingOR,
  title={Programming of rat adrenal medulla by neonatal hyperleptinemia: adrenal morphology, catecholamine secretion, and leptin signaling pathway.},
  author={I. H. Trevenzoli and C{\'i}ntia R Pinheiro and Ellen Paula Santos Conceiç{\~a}o and Elaine de Oliveira and Magna Cottini Fonseca Passos and Patr{\'i}cia Cristina Lisboa and Egberto Gaspar de Moura},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2010},
  volume={298 5},
  pages={
          E941-9
        }
}
Leptin serum concentration in early life is an important factor for adequate future development of the offspring. Previously, we demonstrated that hyperleptinemia on lactation programmed for hyperleptinemia, central leptin resistance with lower expression of the long form of leptin receptor at hypothalamus, and higher medullary catecholamine levels with cardiovascular consequences at adulthood. The central objective of this study was to determine the direct effect of leptin on adrenal medullary… 
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