Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity

Abstract

For centuries after its first description by Galen, the thymus was considered as only a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes. A unique thymus first appeared in cartilaginous fishes some 500 million years ago, at the same time or shortly after… (More)
DOI: 10.3389/fnins.2013.00187

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