Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.

@article{Gardner2005ProgrammingOG,
  title={Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.},
  author={David S. Gardner and K. J. Tingey and Bregje W van Bon and Susan E. Ozanne and Vicky Wilson and Jennifer Dandrea and Duane H. Keisler and Terence Stephenson and Michael E. Symonds},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={289 4},
  pages={
          R947-54
        }
}
  • D. GardnerK. Tingey M. Symonds
  • Published 1 October 2005
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
The present study examines the effects of late vs. early gestation undernutrition on adult glucose-insulin homeostasis in sheep and investigates whether the lower birth weight of twins alters glucose-insulin handling in adult life. Pregnant sheep were fed to requirement (100% intake) from day 0 of gestation to term [ approximately 147 days of gestation (dGA), control singles (CS) n = 5; control twins (CT) n = 5] or to 50% requirement from days 0-30 dGA [nutrient restricted during early… 
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248 Citations
Highly Influential Citations
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Background Citations
109
Methods Citations
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Results Citations
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248 Citations

Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep.

The early-life environment has implications for risk of adult-onset diseases, such as glucose intolerance, insulin insensitivity, and obesity, effects that may occur with or without reduced birth…

Adult-Onset Obesity Reveals Prenatal Programming of Glucose-Insulin Sensitivity in Male Sheep Nutrient Restricted during Late Gestation

This study indicates generalised metabolic dysfunction with adult-onset obesity which also exacerbates and ‘reveals’ programming of glucose-insulin sensitivity in male offspring prenatally exposed to maternal undernutrition during late gestation.

Glucose homeostasis and metabolic adaptation in the pregnant and lactating sheep are affected by the level of nutrition previously provided during her late fetal life.

Effects of ewe size and nutrition during pregnancy on glucose metabolism, fat metabolism and adrenal function of postpubertal female twin offspring

Dam size had no effect on glucose metabolism, adrenal function or fat metabolism in 16-month-old female twin offspring, and results indicate that M-ewes could have an advantage over A-ewe in physiological stressful situations in life (e.g. pregnancy, lactation) as their liver may be able to supply more glucose to support their growing conceptus and milk production to increase the chances of survival of their offspring.

Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring.

It is demonstrated that a bout of maternal undernutrition during early to midgestation in sheep increased BW and fat deposition during adolescence and dysregulated glucose uptake in the absence of any change in birth weight.

Maternal nutritional restriction during late gestation impairs development of the reproductive organs in both male and female lambs.

The negative effects of a short period of maternal undernutrition at conception on the glucose-insulin system of offspring in sheep.

Programming of intermediate metabolism in young lambs affected by late gestational maternal undernourishment.

When lambs entered adolescence (19 wk), the effects of late prenatal malnutrition on the glucose-insulin homeostasis and metabolism were manifested: LOW lambs had less insulin-secretory capacity, but this was apparently compensated for by increased target tissue sensitivity for insulin, and adipose lipolytic capacity increased during fasting.

Effect of protein restriction of bovine dams during late gestation on offspring postnatal growth, glucose-insulin metabolism and IGF-1 concentration

Periconceptional Undernutrition of Ewes Impairs Glucose Tolerance in Their Adult Offspring

It is concluded that maternal undernutrition around the time of conception results in impaired glucose tolerance in postpubertal offspring.
...

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