Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.

  title={Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition.},
  author={David S. Gardner and K. J. Tingey and Bregje W van Bon and Susan E. Ozanne and Vicky Wilson and Jennifer Dandrea and Duane H. Keisler and Terence Stephenson and Michael E. Symonds},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={289 4},
  • D. GardnerK. Tingey M. Symonds
  • Published 1 October 2005
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
The present study examines the effects of late vs. early gestation undernutrition on adult glucose-insulin homeostasis in sheep and investigates whether the lower birth weight of twins alters glucose-insulin handling in adult life. Pregnant sheep were fed to requirement (100% intake) from day 0 of gestation to term [ approximately 147 days of gestation (dGA), control singles (CS) n = 5; control twins (CT) n = 5] or to 50% requirement from days 0-30 dGA [nutrient restricted during early… 

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