Programming of DNA methylation patterns.

@article{Cedar2012ProgrammingOD,
  title={Programming of DNA methylation patterns.},
  author={Howard Cedar and Yehudit Bergman},
  journal={Annual review of biochemistry},
  year={2012},
  volume={81},
  pages={97-117}
}
DNA methylation represents a form of genome annotation that mediates gene repression by serving as a maintainable mark that can be used to reconstruct silent chromatin following each round of replication. During development, germline DNA methylation is erased in the blastocyst, and a bimodal pattern is established anew at the time of implantation when the entire genome gets methylated while CpG islands are protected. This brings about global repression and allows housekeeping genes to be… CONTINUE READING

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