Programming DNA Tube Circumferences

  title={Programming DNA Tube Circumferences},
  author={Peng Yin and Rizal F. Hariadi and Sudheer Sahu and Harry M. T. Choi and Sung Ha Park and Thomas H. LaBean and John H. Reif},
  pages={824 - 826}
Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. [] Key Method We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

Large Chiral Nanotubes Self-Assembled by DNA Bricks.

An approach to program the width of DNA helical tubes by controlling the rigidity and curvature of repeating units via single-stranded bricks strategy is reported, which can be controlled by its thickness and the curvature can be tuned by double-helical twist density.

Self-Assembled DNA Tubes Forming Helices of Controlled Diameter and Chirality.

Self-assembly of micrometer-sized helical DNA nanotubes with widely controllable helical diameters ranging from tens of nanometers to a few micrometers are reported.

Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds.

"Nunchucks," potential mechanical magnifiers of nanoscale dynamics consisting of two nanotubes connected by a dsDNA linker, form at yields sufficient for application and consistent with models.

Self-assembly of DNA rings from scaffold-free DNA tiles.

We report a scaffold-free approach in which four- and six-helix DNA bundle units, assembled from a small number of single stranded DNA oligonucleotides precisely arranged in networks of contiguous


In the field of structural DNA nanotechnology, researchers create artificial DNA sequences to self-assemble into target molecular superstructures and nanostructures. The well-understood Watson–Crick

A Compact DNA Cube with Side Length 10 nm.

A small and compact DNA cube with zeptoliter volume is constructed by means of a generalized DNA brick concept using short synthetic oligonucleotides with varying lengths. By mimicking design

DNA origami-based nanoribbons: assembly, length distribution, and twist

It is quantitatively shown that the length distribution of origami ribbons obtained with this technique follows the theoretical prediction for a simple linear polymerization reaction.

A study on a special DNA nanotube assembled from two single-stranded tiles

A simple and efficient method to build DNA nanotubes using only 2 SSTs via one-pot annealing through a hierarchical pathway that involved an intermediate formation of 2-SST nano-lines is reported.

Programming the Curvatures in Reconfigurable DNA Domino Origami by Using Asymmetric Units.

A new method is reported to design DNA origami structures that can transform between a noncurved conformation and curved conformation, developed on the basis of dynamic DNA domino origami.



Self-assembly of chiral DNA nanotubes.

A system of DNA "tiles" that is designed to assemble to form two-dimensional arrays is observed to form narrow ribbons several micrometers in length that are proposed to be arrays that have curled and closed on themselves to form tubes.

DNA tile based self-assembly: building complex nanoarchitectures.

This Review first summarizes the currently available DNA tile toolboxes and further emphasizes recent developments toward self-assembling DNA nanostructures with increasing complexity.

Design and self-assembly of two-dimensional DNA crystals

The design and observation of two-dimensional crystalline forms of DNA that self-assemble from synthetic DNA double-crossover molecules that create specific periodic patterns on the nanometre scale are reported.

DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires

On the basis of a two-step metallization procedure, the 4 x 4 nanoribbons acted as an excellent scaffold for the production of highly conductive, uniform-width, silver nanowires.

Design and characterization of programmable DNA nanotubes.

A new type of nanotube made from DNA double-crossover molecules (DAE-E tiles) is reported and described, explained by a simple model based on the geometry and energetics of B-form DNA.

Design of minimally strained nucleic Acid nanotubes.

A practical theoretical framework is presented for designing and classifying minimally strained nucleic acid nanotubes. The structures are based on the double crossover motif where each

A study of DNA tube formation mechanisms using 4-, 8-, and 12-helix DNA nanostructures.

The DNA nanostructures and their self- assembly demonstrated herein not only provide a new repertoire of scaffolds to template the organization of nanoscale materials, but may also provide useful information for investigating other self-assembly systems.

An Overview of Structural DNA Nanotechnology

  • N. Seeman
  • Biology, Chemistry
    Molecular biotechnology
  • 2007
Structural DNA Nanotechnology uses unusual DNA motifs to build target shapes and arrangements, leading to branched systems with many strands and multiple helical domains and the use of periodic arrays.

Six-helix bundles designed from DNA.

By atomic force microscopy well-formed arrays of hexagonal six-helix bundle motifs both in 1D and in 2D are demonstrated.

Three-helix bundle DNA tiles self-assemble into 2D lattice or 1D templates for silver nanowires.

We present a DNA nanostructure, the three-helix bundle (3HB), which consists of three double helical DNA domains connected by six immobile crossover junctions such that the helix axes are not