Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins.

@article{CailletFauquet1990ProgrammedKO,
  title={Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins.},
  author={Perrine Caillet-Fauquet and Manos Perros and Annick Brandenburger and Pierre Spegelaere and Jean Rommelaere},
  journal={The EMBO journal},
  year={1990},
  volume={9 9},
  pages={2989-95}
}
Although its dependence on the target cell type is well established, the cytopathogenicity of parvoviruses has remained elusive to date as far as its mechanism is concerned. However, indirect evidence suggested that parvoviral non-structural (NS) proteins may be the cytotoxic effectors. In order to test this hypothesis, a molecular clone of parvovirus MVMp was modified, by replacing the P4 promoter of the NS transcription unit by the glucocorticoid-inducible promoter of the mouse mammary tumour… CONTINUE READING