Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis.

  title={Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis.},
  author={Sumiko Adachi and Kazunori Minamisawa and Yoko Okushima and Soichi Inagaki and Kaoru Yoshiyama and Youichi Kondou and Eli Kaminuma and Mika Kawashima and Tetsuro Toyoda and Minami Matsui and Daisuke Kurihara and Sachihiro Matsunaga and Masaaki Umeda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 24},
Genome integrity is continuously threatened by external stresses and endogenous hazards such as DNA replication errors and reactive oxygen species. The DNA damage checkpoint in metazoans ensures genome integrity by delaying cell-cycle progression to repair damaged DNA or by inducing apoptosis. ATM and ATR (ataxia-telangiectasia-mutated and -Rad3-related) are sensor kinases that relay the damage signal to transducer kinases Chk1 and Chk2 and to downstream cell-cycle regulators. Plants also… CONTINUE READING
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