Programmed folding of DNA origami structures through single-molecule force control.

@article{Bae2014ProgrammedFO,
  title={Programmed folding of DNA origami structures through single-molecule force control.},
  author={Wooli Bae and Kipom Kim and Duyoung Min and Je-Kyung Ryu and Changbong Hyeon and Tae-Young Yoon},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={5654}
}
Despite the recent development in the design of DNA origami, its folding yet relies on thermal or chemical annealing methods. We here demonstrate mechanical folding of the DNA origami structure via a pathway that has not been accessible to thermal annealing. Using magnetic tweezers, we stretch a single scaffold DNA with mechanical tension to remove its secondary structures, followed by base pairing of the stretched DNA with staple strands. When the force is subsequently quenched, folding of the… CONTINUE READING

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Recent advances in magnetic tweezers

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