Programmed death-1 checkpoint blockade in acute myeloid leukemia.

@article{Sehgal2015ProgrammedDC,
  title={Programmed death-1 checkpoint blockade in acute myeloid leukemia.},
  author={Alison Sehgal and Theresa L Whiteside and Michael Boyiadzis},
  journal={Expert opinion on biological therapy},
  year={2015},
  volume={15 8},
  pages={1191-203}
}
INTRODUCTION Immune checkpoints are regulatory pathways induced in activated T lymphocytes that regulate antigen responsiveness. These immune checkpoints are hijacked by tumors to promote dysfunction of anti-tumor effector cells and consequently of tumor escape from the host immune system. AREAS COVERED Programmed death-1/programmed death ligand (PD-1/PDL-1), a checkpoint pathway, has been extensively investigated in leukemia mouse models. Expression of PD-1 on the surface of activated immune… CONTINUE READING
Highly Cited
This paper has 108 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
10 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

109 Citations

050100150201620172018
Citations per Year
Semantic Scholar estimates that this publication has 109 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…