Programmed death-1 checkpoint blockade in acute myeloid leukemia.

  title={Programmed death-1 checkpoint blockade in acute myeloid leukemia.},
  author={Alison Sehgal and Theresa L Whiteside and Michael Boyiadzis},
  journal={Expert opinion on biological therapy},
  volume={15 8},
INTRODUCTION Immune checkpoints are regulatory pathways induced in activated T lymphocytes that regulate antigen responsiveness. These immune checkpoints are hijacked by tumors to promote dysfunction of anti-tumor effector cells and consequently of tumor escape from the host immune system. AREAS COVERED Programmed death-1/programmed death ligand (PD-1/PDL-1), a checkpoint pathway, has been extensively investigated in leukemia mouse models. Expression of PD-1 on the surface of activated immune… CONTINUE READING
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