Programmed death 1 and cytokine inducible SH2-containing protein dependent expansion of regulatory T cells upon stimulation With Mycobacterium tuberculosis.

@article{Periasamy2011ProgrammedD1,
  title={Programmed death 1 and cytokine inducible SH2-containing protein dependent expansion of regulatory T cells upon stimulation With Mycobacterium tuberculosis.},
  author={Sivakumar Periasamy and Rohan Dhiman and Peter F. Barnes and Padmaja Paidipally and Amy R. Tvinnereim and Anuradha Bandaru and Vijaya Lakshmi Valluri and Ramakrishna Vankayalapati},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 9},
  pages={1256-63}
}
We previously found that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) expand in response to Mycobacterium tuberculosis infection in individuals who are healthy tuberculin reactors, but not in tuberculin-negative individuals. We also found that the M. tuberculosis mannose-capped lipoarabinomannan and prostaglandin E2 produced by monocytes are involved in Treg expansion. In this study, we found that Tregs expanded from CD4(+)CCR4(+) cells but not from CCR4(-) cells. However, introduction of… CONTINUE READING

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