Programmed contraction of CD8+ T cells after infection

  title={Programmed contraction of CD8+ T cells after infection},
  author={V. Badovinac and Brandon B. Porter and J. Harty},
  journal={Nature Immunology},
  • V. Badovinac, Brandon B. Porter, J. Harty
  • Published 2002
  • Biology, Medicine
  • Nature Immunology
  • The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of antigen-specific CD8+ T cell expansion and the ensuing contraction to a stable number of memory cells. We show that CD8+ T cell expansion after Listeria monocytogenes infection was primarily dependent on the initial infection dose or amount of antigen displayed, and was also influenced by the rate of pathogen clearance. However, the onset and kinetics of CD8+ T cell contraction after L… CONTINUE READING
    Duration of Infection and Antigen Display Have Minimal Influence on the Kinetics of the CD4+ T Cell Response to Listeria monocytogenes Infection1
    • 96
    • Open Access
    Manipulating the Rate of Memory CD8+ T Cell Generation after Acute Infection1
    • 125
    • Open Access
    Feedback regulation of pathogen-specific T cell priming.
    • 214
    • Open Access
    Enumeration of Cytotoxic CD8 T Cells Ex Vivo during the Response to Listeria monocytogenes Infection
    • 11
    • Open Access
    Regulation of CD8+ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host1
    • 142
    • Open Access


    Publications referenced by this paper.
    Cutting Edge: Antigen-Independent CD8 T Cell Proliferation
    • 304
    • Open Access