Programmed contraction of CD8+ T cells after infection

  title={Programmed contraction of CD8+ T cells after infection},
  author={Vladimir P Badovinac and Brandon B. Porter and John T Harty},
  journal={Nature Immunology},
The extent of infection and rate of pathogen clearance are thought to determine both the magnitude of antigen-specific CD8+ T cell expansion and the ensuing contraction to a stable number of memory cells. We show that CD8+ T cell expansion after Listeria monocytogenes infection was primarily dependent on the initial infection dose or amount of antigen displayed, and was also influenced by the rate of pathogen clearance. However, the onset and kinetics of CD8+ T cell contraction after L… CONTINUE READING
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