Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection

@article{Eto2015ProgrammedCD,
  title={Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection},
  author={Shohei Eto and Kozo Yoshikawa and Masaaki Nishi and Jun Higashijima and Takuya Tokunaga and Toshihiro Nakao and Hideya Kashihara and Chie Takasu and T Hisato Iwata and Mitsuo Shimada},
  journal={Gastric Cancer},
  year={2015},
  volume={19},
  pages={466-471}
}
Programmed cell death protein 1 (PD-1) and its ligand PD-L1 downregulate T cell activation and are related to immune tolerance. The aim of this study was to clarify the significance of PD-1 and PD-L1 expression and to analyze the relationships among PD-1, PD-L1, and Foxp3 expression in gastric cancer. A total of 105 patients who underwent curative gastrectomy for stage II/III gastric cancer were included in this study. PD-1, PD-L1, and Foxp3 expression were examined by immunohistochemistry and… CONTINUE READING
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