Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency.

@article{Razvi1993ProgrammedCD,
  title={Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency.},
  author={E S Razvi and Raymond M. Welsh},
  journal={Journal of virology},
  year={1993},
  volume={67 10},
  pages={5754-65}
}
Acute viral infections induce immune deficiencies, as shown by unresponsiveness to mitogens and unrelated antigens. T lymphocytes isolated from mice acutely infected with lymphocytic choriomeningitis virus (LCMV) were found in this study to undergo activation-induced apoptosis upon signalling through the T-cell receptor (TcR)-CD3 complex. Kinetic studies… CONTINUE READING