Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity.

@article{Kerzerho2013ProgrammedCD,
  title={Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity.},
  author={J{\'e}r{\^o}me Kerzerho and Hadi Maazi and Anneliese O Speak and Natacha Szely and Vincent Lombardi and Bryant Khoo and Stacey Geryak and Jonathan Samuel Lam and Pejman Soroosh and Jacques L. van Snick and Omid Akbari},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 4},
  pages={1048-57, 1057.e1-2}
}
BACKGROUND Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying physiologic and immunologic processes are not fully understood. OBJECTIVE The aim of this study was to determine whether TH9 cells develop in vivo in a model of chronic airway hyperreactivity (AHR) and what factors control this development. METHOD We have developed a novel chronic allergen exposure model using the clinically relevant antigen Aspergillus fumigatus to determine the time… CONTINUE READING
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