Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system.

@article{Blaschke1998ProgrammedCD,
  title={Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system.},
  author={Anne J. Blaschke and Joshua A Weiner and Jerold Chun},
  journal={The Journal of comparative neurology},
  year={1998},
  volume={396 1},
  pages={
          39-50
        }
}
During central nervous system (CNS) development, programmed cell death (PCD) has been viewed traditionally as a fate reserved for differentiating neurons that are in the process of making synaptic connections. Recent studies in the embryonic cerebral cortex (Blaschke et al. [1996] Development 122:1165-1174), however, have shown that many neuroblasts in the proliferative ventricular zone undergo PCD as well and that this likely represents a novel form distinct from that found in regions of… CONTINUE READING
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The phenotype of the CPP32 null mouse is so significant that it causes a severalfold increase in the thickness of the neural tube by E12

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