Programmed cell death induced by ceramide.

  title={Programmed cell death induced by ceramide.},
  author={Lina M Obeid and Corinne M. Linardic and L A Karolak and Yusuf A. Hannun},
  volume={259 5102},
Sphingomyelin hydrolysis and ceramide generation have been implicated in a signal transduction pathway that mediates the effects of tumor necrosis factor-alpha (TNF-alpha) and other agents on cell growth and differentiation. In many leukemic cells, TNF-alpha causes DNA fragmentation, which leads to programmed cell death (apoptosis). C2-ceramide (0.6 to 5 microM), a synthetic cell-permeable ceramide analog, induced internucleosomal DNA fragmentation, which was inhibited by zinc ion. Other… CONTINUE READING
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