Programmed cell death in the nematode C. elegans.

@article{Hengartner1999ProgrammedCD,
  title={Programmed cell death in the nematode C. elegans.},
  author={Michael O. Hengartner},
  journal={Recent progress in hormone research},
  year={1999},
  volume={54},
  pages={213-22; discussion 222-4}
}
Programmed cell death is a common feature during animal development. In the nematode C. elegans, more than 12 genes have been identified that function in the apoptotic killing and elimination of 131 of the 1090 cells that are generated during hermaphrodite development. These genes divide the process of programmed cell death into three distinct steps: execution of the death sentence; engulfment of dying cells; and degradation of dead, engulfed cells. Biochemical characterization of the genes in… CONTINUE READING

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