Programmed cell death in AIDS-related HIV and SIV infections.

  title={Programmed cell death in AIDS-related HIV and SIV infections.},
  author={M L Gougeon and Sylvie Garcia and Jonathan Luke Heeney and R Tschopp and Herv{\'e} Lecoeur and Denise Gu{\'e}tard and V Rame and Charlie Dauguet and Luc Montagnier},
  journal={AIDS research and human retroviruses},
  volume={9 6},
One of the difficulties in understanding the complex pathology of human immunodeficiency virus (HIV) infection is to explain the progressive depletion of the CD4 helper T cell population and consequently the destruction of the immune system. Although cytopathic effects of HIV are observed in vitro, they cannot in vivo account for CD4 T cell depletion because relatively few cells are productively infected. Thus immunological mechanisms must be envisaged. We have found that peripheral blood… CONTINUE READING


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