Programmed cell death and the control of cell survival.

  title={Programmed cell death and the control of cell survival.},
  author={Martin C. Raff and Ben A Barres and Julia F. Burne and Hilary Coles and Yasuki Ishizaki and Michael D. Jacobson},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={345 1313},
We draw the following tentative conclusions from our studies on programmed cell death (PCD): (i) the amount of normal cell death in mammalian development is still underestimated; (ii) most mammalian cells constitutively express the proteins required to undergo PCD; (iii) the death programme operates by default when a mammalian cell is deprived of signals from other cells; (iv) many normal cell deaths may occur because cells fail to obtain the extracellular signals they need to suppress the… CONTINUE READING

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