Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma

@inproceedings{Reis2010ProgrammedCD,
  title={Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma},
  author={Patricia Pintor dos Reis and Miranda Tomenson and Nilva de Karla Cervigne and Jerry Machado and Igor Jurisica and Melania Pintilie and Mahadeo A Sukhai and Bayardo Perez-Ord{\'o}{\~n}ez and Reidar Axel Grenman and Ralph W. Gilbert and Patrick J. Gullane and Jonathan C. Irish and Suzanne Kamel-Reid},
  booktitle={Molecular Cancer},
  year={2010}
}
The tumor suppressor Programmed Cell Death 4 (PDCD4) has been found to be under-expressed in several cancers and associated with disease progression and metastasis. There are no current studies characterizing PDCD4 expression and its clinical relevance in Oral Squamous Cell Carcinoma (OSCC). Since nodal metastasis is a major prognostic factor in OSCC, we focused on determining whether PDCD4 under-expression was associated with patient nodal status and had functional relevance in OSCC invasion… CONTINUE READING