Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance.

@article{Wang2007ProgrammedCD,
  title={Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance.},
  author={Liqing Wang and Rongxiang Han and Wayne W Hancock},
  journal={European journal of immunology},
  year={2007},
  volume={37 10},
  pages={2983-90}
}
Programmed cell death-1 (PD-1, CD279) and its widely expressed, inducible ligand, PD-L1 (CD274), together dampen T cell activation, but whether they are essential for allograft tolerance is unknown. We show, using gene-deficient mice and blocking mAbs in wild-type mice, that costimulation blockade is ineffectual in PD-1(-/-) or PD-L1(-/-) allograft recipients, or in wild-type allograft recipients treated with anti-PD-1 or anti-PD-L1 mAb. Alloreactive PD-1(-/-) CD4 and CD8 T cells had enhanced… CONTINUE READING

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