Programmed axon death, synaptic dysfunction and the ubiquitin proteasome system.

@article{Coleman2004ProgrammedAD,
  title={Programmed axon death, synaptic dysfunction and the ubiquitin proteasome system.},
  author={Michael P. Coleman and Richard R Ribchester},
  journal={Current drug targets. CNS and neurological disorders},
  year={2004},
  volume={3 3},
  pages={227-38}
}
Axons are essential, vulnerable and often irreplaceable so it is essential to understand how they are lost in neurodegenerative disease. Recent data link the mechanism of injury-induced Wallerian degeneration to that of axon death in CNS and PNS disease. The neuroprotective gene Wld(S) delays Wallerian degeneration, CNS axonal dystrophy, 'dying-back' pathology and to a lesser extent synapse loss, despite the different causes and morphologies of degeneration. These findings validate Wallerian… CONTINUE READING
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