Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.

@article{Rusten2004ProgrammedAI,
  title={Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.},
  author={Tor Erik Rusten and Karine Lindmo and G{\'a}bor Juh{\'a}sz and Mikl{\'o}s Sass and Per O. Seglen and Andreas Brech and Harald Stenmark},
  journal={Developmental cell},
  year={2004},
  volume={7 2},
  pages={179-92}
}
Eukaryotic cells catabolize their own cytoplasm by autophagy in response to amino acid starvation and inductive signals during programmed tissue remodeling and cell death. The Tor and PI3K signaling pathways have been shown to negatively control autophagy in eukaryotes, but the mechanisms that link these effectors to overall animal development and nutritional status in multicellular organisms remain poorly understood. Here, we reveal a complex regulation of programmed and starvation-induced… CONTINUE READING
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