Programmed administration of parathyroid hormone increases bone formation and reduces bone loss in hindlimb-unloaded ovariectomized rats.

@article{Turner1998ProgrammedAO,
  title={Programmed administration of parathyroid hormone increases bone formation and reduces bone loss in hindlimb-unloaded ovariectomized rats.},
  author={Russell T. Turner and Glenda L. Evans and J M Cavolina and Bernard Halloran and Emily R. Morey-Holton},
  journal={Endocrinology},
  year={1998},
  volume={139 10},
  pages={
          4086-91
        }
}
Gonadal insufficiency and reduced mechanical usage are two important risk factors for osteoporosis. The beneficial effects of PTH therapy to reverse the estrogen deficiency-induced bone loss in the laboratory rat are well known, but the influence of mechanical usage in this response has not been established. In this study, the effects of programed administration of PTH on cancellous bone volume and turnover at the proximal tibial metaphysis were determined in hindlimb-unloaded, ovariectomized… CONTINUE READING

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