Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism.

@article{Kataoka2011ProgrammedDE,
  title={Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism.},
  author={Kensuke Kataoka and Kazufumi Mochizuki},
  journal={Advances in experimental medicine and biology},
  year={2011},
  volume={722},
  pages={156-73}
}
RNA interference (RNAi) was initially discovered as a post-transcriptional gene silencing mechanism in which short RNAs are used to target complementary RNAs for degradation. During the past several years, it has been demonstrated that RNAi-related processes are also involved in transcriptional gene silencing by directing formation of heterochromatin. The dynamic DNA rearrangement during sexual reproduction of the ciliated protozoan Tetrahymena provides an extreme example of RNAi-directed… CONTINUE READING