Programmed Cell Senescence during Mammalian Embryonic Development

@article{MuozEspn2013ProgrammedCS,
  title={Programmed Cell Senescence during Mammalian Embryonic Development},
  author={Daniel Mu{\~n}oz-Esp{\'i}n and M. Ά. Bl{\'a}zquez Ca{\~n}amero and Antonio G{\'o}mez-Guillam{\'o}n Maraver and Gonzalo G{\'o}mez-L{\'o}pez and Julio Gim{\'e}nez Contreras and Silvia Murillo-Cuesta and Alfonso Rodr{\'i}guez-Baeza and Isabel Varela-Nieto and Jes{\'u}s Ruberte and M. C. Real Collado and Manuel Serrano},
  journal={Cell},
  year={2013},
  volume={155},
  pages={1104-1118}
}
Cellular senescence disables proliferation in damaged cells, and it is relevant for cancer and aging. Here, we show that senescence occurs during mammalian embryonic development at multiple locations, including the mesonephros and the endolymphatic sac of the inner ear, which we have analyzed in detail. Mechanistically, senescence in both structures is strictly dependent on p21, but independent of DNA damage, p53, or other cell-cycle inhibitors, and it is regulated by the TGF-β/SMAD and PI3K… CONTINUE READING
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