Programmed Cell Death in Neuronal Development

@article{Dekkers2013ProgrammedCD,
  title={Programmed Cell Death in Neuronal Development},
  author={Martijn P J Dekkers and Yves-Alain Barde},
  journal={Science},
  year={2013},
  volume={340},
  pages={39 - 41}
}
Life or death decisions in cortical interneurons during development are made independently of external cues, challenging current theory. Programmed cell death, or apoptosis, accompanies the development of many tissues, including the vertebrate nervous system. Most neurons are eliminated soon after synaptic contacts have been made between the neurons and their targets. This inspired the neurotrophic theory, which proposes that neurons compete for limited quantities of target-derived survival… 
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References

SHOWING 1-10 OF 12 REFERENCES
Intrinsically determined cell death of developing cortical interneurons
TLDR
The findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons.
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
TLDR
It is suggested that the expansion of the Trk gene family that accompanied the segregation of the peripheral from the central nervous system generated a novel mechanism of cell number control, explaining why developing sympathetic and sensory neurons become trophic-factor-dependent for survival.
Adaptive roles of programmed cell death during nervous system development.
TLDR
The programmed cell death of developing cells is considered an essential adaptive process that evolved to serve diverse roles and perturb (inhibit) PCD is reviewed to determine the possible repercussions for nervous system development and function.
Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth
TLDR
It is found that BDNF markedly promotes the growth of cultured striatal neurons and of their dendrites, but not of those of hippocampal neurons, suggesting that the differential responsiveness to BDNF is part of a neuron-intrinsic program.
The Fraction of Cortical GABAergic Neurons Is Constant from Near the Start of Cortical Neurogenesis to Adulthood
TLDR
The data indicate the one-in-five fraction of GABAergic neurons is already established during their neuronal migration and well before significant synapse formation, suggesting a critical balance between inhibition and excitation in adult circuits is established.
Control of Apoptosis by Asymmetric Cell Division
TLDR
This work shows that asymmetric cell division in the nematode Caenorhabditis elegans is mediated by a pathway involving three genes that directly control the enzymatic machinery responsible for apoptosis, and proposes that this pathway directly controls the apoptotic fate in C. elegans, and possibly other animals as well.
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
TLDR
It is shown that germ cells, which in hermaphrodites can differentiate into sperm and oocytes, also undergo apoptotic cell death, and it is suggested that apoptosis eliminates excess germ cells that acted as nurse cells to provide cytoplasmic components to maturing oocytes.
Relationship of the time of origin and death of neurons in rat somatosensory cortex: Barrel versus septal cortex and projection versus local circuit neurons
  • M. Miller
  • Biology, Medicine
    The Journal of comparative neurology
  • 1995
TLDR
Whether there is a relationship between the generation and death of cortical neurons and neurons that successfully integrate into the cortical circuitry is determined.
The nerve growth factor 35 years later.
TLDR
The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.
  • S. Korsching, H. Thoenen
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1983
A two-site enzyme immunoassay is described which does not suffer from artifacts inherent in previous assays and has the necessary high sensitivity to determine the endogenous levels of nerve growth
...
1
2
...