Programmed Cell Death (PCD): Apoptosis, Autophagic PCD, or Others?

@article{Bursch2000ProgrammedCD,
  title={Programmed Cell Death (PCD): Apoptosis, Autophagic PCD, or Others?},
  author={Wilfried Bursch and Adolf Ellinger and Christopher Gerner and Ulrike Fröhwein and Rolf Schulte‐Hermann},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={926}
}
Abstract: The occurrence of cell death as a physiological event in multicellular organisms has been known for more than 150 years; in 1972 the term apoptosis was introduced on morphological grounds. However, accumulating evidence suggests that programmed cell death (PCD) is not confined to apoptosis, but that cells use different pathways for active self‐destruction as reflected by different morphology: condensation prominent, type I or apoptosis; autophagy prominent, type II; etc. Autophagic… Expand
The autophagosomal–lysosomal compartment in programmed cell death
  • W. Bursch
  • Biology, Medicine
  • Cell Death and Differentiation
  • 2001
In the last decade a tremendous progress has been achieved in understanding the control of apoptosis by survival and death factors as well as the molecular mechanisms of preparation and execution ofExpand
Programmed cell death via mitochondria: Different modes of dying
TLDR
The central role of the mitochondrion in the integration of the cell death pathways is discussed and the mitochondria can be viewed as a central regulator of the decision between cellular survival and demise. Expand
Detection of epithelial cell death in the body by cytokeratin 18 measurement.
TLDR
Monitoring serum levels of K18 may be a promising approach for early detection of therapeutic effects and the levels of different forms of K 18 might indicate the mode of cell death occurring in the body. Expand
Molecular Pathways of Different Types of Cell Death: Many Roads to Death
TLDR
It is debatable whether autophagic cell death is an alternative way of dying, different from apoptotic and necrotic cell death, or whether failure of autophagy to rescue the cell can lead to cell death by either pathway. Expand
Chapter 1 – Molecular Mechanisms of Cell Death
Cell death is a fundamental pathophysiological process and also an essential event in normal life and development. Although many stimuli cause death of cells, the mode of cell death typically followsExpand
Apoptosis and Other Alternate Mechanisms of Cell Death
TLDR
Overall, cell death have clarified many aspects of this fundamental process and brought to the attention of scientists its role in a large number of different diseases. Expand
APOPTOTIC PATHWAYS AND THEIR REGULATION Chapter I
TLDR
The central role of apoptosis in homeostasis and cell renewal is also illustrated by the fact that anti-apoptotic mechanisms are crucial in tumorigenesis and therapeutic resistance. Expand
Chondroptosis: A variant of apoptotic cell death in chondrocytes?
TLDR
The term ‘chondroptosis’ is proposed to reflect the fact that such cells are undergoing apoptosis in a non-classical manner that appears to be typical of programmed chondrocyte death in vivo, and it is speculated that the endoplasmic reticulum pathway of apoptosis plays a greater role than receptor-mediated or mitochondrial pathways and that lysosomal proteases are at least as important as caspases. Expand
Human granulocytes undergo cell death via autophagy
TLDR
It is found that during differentiation, autophagy inhibitor 3-MA, and not caspase inhibitor zVAD-fmk, prevented segmentation of the nucleus, indicating that human neutrophils may undergo spontaneous autophagic cell death rather than apoptosis, during which autophamy may be essential for both maturation and death. Expand
Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors
TLDR
Autophagy is deeply related to the cell survival system and that inhibition of autophagy accelerates TPA‐ or imatinib‐induced cell death, and the block of Autophagy could be a new strategy in the treatment of CML. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 85 REFERENCES
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments.
TLDR
The concept that autophagic cell death is a separate entity of programmed cell death that is distinctly different from apoptosis is supported, even beyond the stage of nuclear collapse. Expand
Cell death: programmed, apoptosis, necrosis, or other?
TLDR
The requirement for protein synthesis is more characteristic of Type II cell death in developmental situations than it is for Type I cell death, and the variations seen force a reassessment of those aspects of physiological cell death that are truly universal. Expand
Do all programmed cell deaths occur via apoptosis?
TLDR
Comparing the patterns of cell death displayed by T cells and the intersegmental muscles is compared and it is found that they differ in terms of cell-surface morphology, nuclear ultrastructure, DNA fragmentation, and polyubiquitin gene expression. Expand
Caspase-independent programmed cell death with necrotic morphology
TLDR
The existence of a necrotic-like cell death regulated by cellular intrinsic death programs distinct from that of apoptosis is suggested. Expand
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
TLDR
Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression. Expand
Apoptosis, oncosis, and necrosis. An overview of cell death.
TLDR
Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage. Expand
Cell death: the significance of apoptosis.
TLDR
It has proved feasible to categorize most if not all dying cells into one or the other of two discrete and distinctive patterns of morphological change, which have, generally, been found to occur under disparate but individually characteristic circumstances. Expand
Programmed cell death in Dictyostelium.
TLDR
These traits exhibit some similarity to those of previously described non-apoptotic and apoptotic PCD, suggesting the hypothesis of a single core molecular mechanism of PCD emerging in evolution before the postulated multiple emergences of multicellularity. Expand
Alterations in cytoskeletal and nuclear matrix-associated proteins during apoptosis.
TLDR
Investigating changes in the nuclear organization in spontaneously occurring apoptotic cells in several cancer cell lines using several antibodies to nuclear matrix constituents found that nuclear matrix components remained detectable in cells undergoing spontaneous apoptosis. Expand
Apoptosis and carcinogenesis.
This article attempts to summarize the rapidly advancing field of apoptosis and its regulation, with particular reference to cancer. The long-recognized stereotyped morphology of apoptosis is seen toExpand
...
1
2
3
4
5
...