Programmed Anuclear Cell Death Delimits Platelet Life Span

  title={Programmed Anuclear Cell Death Delimits Platelet Life Span},
  author={K. Mason and M. Carpinelli and J. Fletcher and Janelle E. Collinge and A. Hilton and S. Ellis and P. Kelly and P. Ekert and D. Metcalf and A. Roberts and D. Huang and B. T. Kile},
  • K. Mason, M. Carpinelli, +9 authors B. T. Kile
  • Published 2007
  • Biology, Medicine
  • Cell
  • Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing. Despite much speculation, the factors determining their life span in the circulation are unknown. We show here that an intrinsic program for apoptosis controls platelet survival and dictates their life span. Pro-survival Bcl-x(L) constrains the pro-apoptotic activity of Bak to maintain platelet survival, but as Bcl-x(L) degrades, aged platelets are primed for cell death. Genetic ablation or… CONTINUE READING

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