Programmable single-cell mammalian biocomputers

@article{Auslnder2012ProgrammableSM,
  title={Programmable single-cell mammalian biocomputers},
  author={Simon Ausl{\"a}nder and David Ausl{\"a}nder and Marius M{\"u}ller and Markus Wieland and Martin Fussenegger},
  journal={Nature},
  year={2012},
  volume={487},
  pages={123-127}
}
Synthetic biology has advanced the design of standardized control devices that program cellular functions and metabolic activities in living organisms. Rational interconnection of these synthetic switches resulted in increasingly complex designer networks that execute input-triggered genetic instructions with precision, robustness and computational logic reminiscent of electronic circuits. Using trigger-controlled transcription factors, which independently control gene expression, and RNA… CONTINUE READING

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